The 2025 Circle of Harmony HIV/AIDS Wellness Conference will take place August 26-28, 2025 at the Isleta Resort and Casino in Albuquerque, NM. The theme, “Cultural Threads of HIV Wellness: Weaving Healing, Partnerships, and Care,” recognizes the unique position of Indigenous communities to weave evidence based strategies with our cultural concepts of healing and care. The Indigenous HIV/AIDS Syndemic Strategy, Ending the HIV Epidemic initiative, and the National HIV/AIDS Strategy will guide our agenda to highlight best practices for implementing PrEP navigation, medication as prevention, and other biomedical strategies for advancing health equity.